A Family Of Products For Critical Size Bone Defects And Skin Wounds With Unmet Medical Needs.

Novadip Biosciences: a family of new generation, 3D therapies based on adipose stem cells, for hard and soft tissue reconstruction.


Market application for NVD-001: bone healing disorders and critical size bone defects with unmet medical needs.

Bone healing disorders and critical size bone defects following degenerative conditions, trauma, infection, congenital deficiency or tumour resection remain a major healthcare issue because of intrinsic difficulties in stabilizing the spine or reconstructing bone segments using bone implants with poor osteoinductive and disappointing osteogenic properties.

NVD-001 is a revolutionary approach to use in neurosurgery for spine fusion or in case of vertebral fractures.

The first clinical cases using a first generation of NVD-001 in orthopaedic surgery (10 patients) showed safety and efficacy, even in salvage situations where other technologies available were unsuccessful (>36 months FU for some patients). These cases were published by VĂ©riter et al, PLoSOne 2015 10(10).

Market application for NVD-002: skin wounds with unmet medical needs.

Various diseases, infections or traumas often result in skin wounds that do not heal spontaneously. Patients with diabetes, vascular ulcers or deep burns are particularly susceptible, and may require reconstructive surgery with skin autografts. However, this treatment is often disappointing because of the limited blood supply from the underlying wound structures prevent successful skin engraftment and cause large painful scars. These aesthetic and functional sequels cause body image distress and pain.

NVD-002 is designed to avoid formation of these scars. It could be applied in different indications including burn hypertrophic scars, chronic wounds in case of radionecrosis and systemic disease such as diabetes.

Potential market segments for critical size bone defects (EU/US p.a.)


Spinal procedures


Bone tumor resections


Patients with osteonecrosis


Patients with non-unions or delayed unions


Patients with vertebral fractures


Patients with severe osteoporosis


Maxillofacial and periodontal treatments